| Registro completo |
| Provedor de dados: |
BJPS
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| País: |
Brazil
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| Título: |
2-Phenitidine derivatives as suitable inhibitors of butyrylcholinesterase
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| Autores: |
Abbasi,Muhammad Athar
Aziz-ur-Rehman,
Qureshi,Muhammad Zahid
Khan,Farhan Mehmood
Khan,Khalid Mohmmed
Ashraf,Muhammad
Afzal,Iftikhar
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| Data: |
2013-03-01
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| Ano: |
2013
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| Palavras-chave: |
2-Phenitidine/inhibitor activity
Sulfonamides
Acetamide
Benzamide
Butyrylcholinesterase
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| Resumo: |
This manuscript reports the synthesis of a series of N-substituted derivatives of 2-phenitidine. First, the reaction of 2-phenitidine (1) with benzene sulfonyl chloride (2) yielded N-(2-ethoxyphenyl) benzenesulfonamide (3), which further on treatment with sodium hydride and alkyl halides (4a-g) furnished into new sulfonamides (5a-g). Second, the phenitidine reacted with benzoyl chloride (6) and acetyl chloride (8) to yield the reported N-benzoyl phenitidine (7) and N-acetyl phenitidine (9), respectively. These derivatives were characterized by infrared spectroscopy, ¹H-NMR, and EI-MS, and then screened against acetylcholinesterase, butylcholinesterase, and lipoxygenase enzyme, and were found to be potent inhibitors of butyrylcholinesterase alone.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502013000100014
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| Editor: |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
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| Relação: |
10.1590/S1984-82502013000100014
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Pharmaceutical Sciences v.49 n.1 2013
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| Direitos: |
info:eu-repo/semantics/openAccess
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